Atherosclerosis development
نویسندگان
چکیده
منابع مشابه
Predicting the development of atherosclerosis.
Atherosclerotic vascular disease is one of the great epidemics of the 21st Century.1 Decades before its clinical manifestation, endothelial dysfunction (ED) marks the beginning of an insidious disease process, which silently progresses to a point where it can only be slowed but not reversed. ED is induced by a variety of mediators, some of which are known and related to established cardiovascul...
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A severe case of stenosis in coronary arteries results in turbulence in the blood flow which may lead to the formation or progression of atherosclerosis. This study investigated the turbulent blood flow in a coronary artery with rigid walls, as well as 80% single and double stenoses on blood flow. A finite element-based software package, ADINA 8.8, was employed to model the blood flow. The hemo...
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Mesenchymal stem cells (MSCs) have regenerative properties, but recently they were also found to have immunomodulatory capacities. We therefore investigated whether MSCs could reduce atherosclerosis, which is determined by dyslipidaemia and chronic inflammation. We adoptively transferred MSCs into low-density lipoprotein-receptor knockout mice and put these on a Western-type diet to induce athe...
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1. White Carneau pigeons develop genetic atherosclerosis. The aorta shows intimal cushions at birth, cholesterol accumulation at 9 months of age and definite atherosclerotic lesions by 3 years of age. To determine whether these age-related arterial changes can be prevented by dietary restriction started early in life, 3-month-old pigeons were subjected to dietary restriction (40% of ad lib. die...
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Atherosclerosis begins as an inflammation in blood vessel walls (intima). The inflammatory response of the organism leads to the recruitment of monocytes. Trapped in the intima, they differentiate into macrophages and foam cells leading to the production of inflammatory cytokines and further recruitment of white blood cells. This self-accelerating process, strongly influenced by low-density lip...
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ژورنال
عنوان ژورنال: Current Opinion in Lipidology
سال: 2017
ISSN: 0957-9672
DOI: 10.1097/mol.0000000000000462